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Unchaining NK cell–mediated anticancer immunosurveillance

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In natural killer (NK) cells, CIS restrains a signaling pathway elicited by interleukin 15 (IL-15) that leads to activation of the kinase JAK1. Removal of CIS from NK cells increases their capacity to reduce the metastatic dissemination of breast cancer and melanoma in mice.

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Figure 1: Effects of CIS on NK cells and T cells in the context of anticancer immunosurveillance.

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Authors and Affiliations

  1. Laurence Zitvogel is with the Gustave Roussy Cancer Campus, Villejuif, France, INSERM U1015, Villejuif, France, Université Paris Sud-XI, Faculté de Médecine, Le Kremlin Bicêtre, France, and the Center of Clinical Investigations in Biotherapies of Cancer 507, Villejuif, France.,

    Laurence Zitvogel

  2. Department of Women's and Children's Health, Guido Kroemer is with the Gustave Roussy Cancer Campus, Villejuif, France, Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, INSERM U 1138, Paris, France, Université Paris Descartes, Sorbonne Paris Cité, Paris, France, Université Pierre & Marie Curie, Paris, France, Metabolomics and Cell Biology Platforms, Gustave Roussy, Villejuif, France, Pôle de Biologie, Hôpital Européen Georges Pompidou, Assistance Publique−Hôpitaux de Paris, Paris, France, and Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.,

    Guido Kroemer

Authors
  1. Laurence Zitvogel
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  2. Guido Kroemer
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Correspondence to Guido Kroemer.

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The authors declare no competing financial interests.

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Zitvogel, L., Kroemer, G. Unchaining NK cell–mediated anticancer immunosurveillance. Nat Immunol 17, 746–747 (2016). https://doi.org/10.1038/ni.3471

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