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Big impact of microRNAs on central B cell tolerance

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The silencing of autoreactive immature B cells is regulated by the binding of self antigens to B cell antigen receptors. New findings show that microRNAs control mechanisms of B cell tolerance.

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Figure 1: Bone marrow selection of immature B cells.

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Authors and Affiliations

  1. Eric Meffre is in the Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.,

    Eric Meffre

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  1. Eric Meffre
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Correspondence to Eric Meffre.

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The author declares no competing financial interests.

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Meffre, E. Big impact of microRNAs on central B cell tolerance. Nat Immunol 17, 353–354 (2016). https://doi.org/10.1038/ni.3414

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