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The NEK-sus of the NLRP3 inflammasome

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The NLRP3 inflammasome has broad biomedical relevance, but its activation mechanisms are incompletely understood. NEK7, a kinase that regulates microtubules during mitosis, is identified as a critical and selective upstream regulator of NLRP3 inflammasome activation.

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Figure 1: Model of NEK7 signaling in activation of the NLRP3 inflammasome.

Marina Corral Spence/Nature Publishing Group

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Authors and Affiliations

  1. and the Department of Internal Medicine, Filip Van Hauwermeiren and Mohamed Lamkanfi are with the Inflammation Research Center, VIB, Ghent, Belgium, Ghent University, Ghent, Belgium.,

    Filip Van Hauwermeiren & Mohamed Lamkanfi

Authors
  1. Filip Van Hauwermeiren
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  2. Mohamed Lamkanfi
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Correspondence to Mohamed Lamkanfi.

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The authors declare no competing financial interests.

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Van Hauwermeiren, F., Lamkanfi, M. The NEK-sus of the NLRP3 inflammasome. Nat Immunol 17, 223–224 (2016). https://doi.org/10.1038/ni.3391

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