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O-linked sugars sound the alarm

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Viral infection of the mucosa induces a strong host innate immune response involving type I interferons and interferon-stimulated genes. New findings show that mechanical or pathogen-induced disruption of the mucus itself can also trigger 'hyper-early' innate responses independent of type I interferons and major sensing pathways of the innate immune system.

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Figure 1: O-linked glycan–based innate response at mucosal surface.

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Authors and Affiliations

  1. Yosuke Kumamoto and Akiko Iwasaki are in the Department of Immunobiology, Smita Gopinath, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA.,

    Smita Gopinath, Yosuke Kumamoto & Akiko Iwasaki

Authors
  1. Smita Gopinath
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  2. Yosuke Kumamoto
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  3. Akiko Iwasaki
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Correspondence to Akiko Iwasaki.

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The authors declare no competing financial interests.

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Gopinath, S., Kumamoto, Y. & Iwasaki, A. O-linked sugars sound the alarm. Nat Immunol 17, 119–120 (2016). https://doi.org/10.1038/ni.3364

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