Understanding cytotoxic T cells has been a major focus of immunology research for decades. Proteomic profiling of these cells now brings them into unprecedented and revealing focus.
References
Schwanhäusser, B. et al. Nature 473, 337–342 (2011).
Hukelmann, J.L. et al. Nat. Immunol. 17, 104–112 (2016).
Wiśniewski, J.R., Hein, M.Y., Cox, J. & Mann, M. Mol. Cell. Proteomics 13, 3497–3506 (2014).
Isaaz, S., Baetz, K., Olsen, K., Podack, E. & Griffiths, G.M. Eur. J. Immunol. 25, 1071–1079 (1995).
Buck, D., O'Sullivan, D. & Pearce, E.L. J. Exp. Med. 212, 1345–1360 (2015).
Cham, C.M., Driessens, G., O'Keefe, J.P. & Gajewski, T.F. Eur. J. Immunol. 38, 2438–2450 (2008).
Castello, A., Hentze, M.W. & Preiss, T. Trends Endocrinol. Metab. http://dx.doi.org/10.1016/j.tem.2015.09.012 (28 October 2015).
Macintyre, A.N. et al. Cell Metab. 20, 61–72 (2014).
Sinclair, L.V. et al. Nat. Immunol. 14, 500–508 (2013).
Xu, X., Ye, L., Araki, K. & Ahmed, s Semin. Immunol. 24, 429–435 (2012).
Intlekofer, A.M. et al. Nat. Immunol. 6, 1236–1244 (2005).
Jha, A.K. et al. Immunity 42, 419–430 (2015).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Sanin, D., Pearce, E. The cell identity of cytotoxic T lymphocytes. Nat Immunol 17, 45–46 (2016). https://doi.org/10.1038/ni.3350
Published:
Issue Date:
DOI: https://doi.org/10.1038/ni.3350
- Springer Nature America, Inc.