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Reversed-polarity Treg cell TCRs provide a shock

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Docking of T cell antigen receptors (TCRs) engaging complexes of peptide and major histocompatibility complex has shown the same diagonal orientation and polarity. A new study demonstrating that TCRs from regulatory T cells bind with reversed polarity challenges this dogma.

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Figure 1: TCR-peptide interactions.

References

  1. Beringer, T. et al. Nat. Immunol. 16, 1153–1161 (2015).

    Article  CAS  Google Scholar 

  2. Attaf, M., Legut, M., Cole, D.K. & Sewell, A.K. Clin. Exp. Immunol. 181, 1–18 (2015).

    Article  CAS  Google Scholar 

  3. Rangarajan, S. & Mariuzza, R.A. Cell. Mol. Life Sci. 71, 3059–3068 (2014).

    Article  CAS  Google Scholar 

  4. Garcia, K.C. Trends Immunol. 33, 429–436 (2012).

    Article  CAS  Google Scholar 

  5. Tungatt, K. et al. J. Immunol. 194, 463–474 (2015).

    Article  CAS  Google Scholar 

  6. Cole, D.K. et al. J. Immunol. 178, 5727–5734 (2007).

    Article  CAS  Google Scholar 

  7. Gagliani, N. et al. Nat. Med. 19, 739–746 (2013).

    Article  CAS  Google Scholar 

  8. Tree, T.I. et al. Diabetes 59, 1451–1460 (2010).

    Article  CAS  Google Scholar 

  9. Arif, S. et al. Diabetes 63, 3835–3845 (2014).

    Article  CAS  Google Scholar 

  10. Arif, S. et al. J. Clin. Invest. 113, 451–463 (2004).

    Article  CAS  Google Scholar 

  11. Gibson, V.B. et al. Clin. Exp. Immunol. doi:10.1111/cei.12687 (22 July 2015).

  12. Thrower, S.L. et al. Clin. Exp. Immunol. 155, 156–165 (2009).

    Article  CAS  Google Scholar 

  13. Burton, B.R. et al. Nat. Commun. 5, 4741 (2014).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Mark Peakman is in the Department of Immunobiology, King's College London, London, UK.,

    Mark Peakman

  2. Andrew K. Sewell is in the Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.,

    Andrew K Sewell

Authors
  1. Mark Peakman
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  2. Andrew K Sewell
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Corresponding authors

Correspondence to Mark Peakman or Andrew K Sewell.

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Competing interests

M.P. and King's College London have a license agreement with UCB Pharma to develop a peptide-based immunotherapy for type 1 diabetes.

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Peakman, M., Sewell, A. Reversed-polarity Treg cell TCRs provide a shock. Nat Immunol 16, 1105–1107 (2015). https://doi.org/10.1038/ni.3289

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