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GBPs take AIM at Francisella

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Guanylate-binding proteins (GBPs) induced by type I interferon signaling cause lysis of Francisella bacteria that have reached the host-cell cytosol. The liberated bacterial DNA is then sensed by the cytosolic AIM2 inflammasome, which activates caspase-1 and leads to pyroptotic cell death.

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Figure 1: IRF1 and GBPs facilitate the release of bacterial DNA into the host cytosol.

Katie Vicari/Nature Publishing Group

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Authors and Affiliations

  1. Department of Medicine, Katherine A. Fitzgerald is in the Program in Innate Immunity, University of Massachusetts Medical School, Worcester, Massachusetts, USA.,

    Katherine A Fitzgerald

  2. Vijay A. K. Rathinam is in the Department of Immunology, University of Connecticut Health Center, Farmington, Connecticut, USA.,

    Vijay A K Rathinam

Authors
  1. Katherine A Fitzgerald
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  2. Vijay A K Rathinam
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Correspondence to Vijay A K Rathinam.

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The authors declare no competing financial interests.

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Fitzgerald, K., Rathinam, V. GBPs take AIM at Francisella. Nat Immunol 16, 443–444 (2015). https://doi.org/10.1038/ni.3144

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