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PTENtiating autoimmunity through Treg cell deregulation

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Regulatory T cells require the phosphatase PTEN to maintain suppressive function in homeostatic conditions through preserved expression of CD25 and the transcription factor Foxp3.

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Figure 1: Treg cells modulate their IL-2 signaling to maintain their suppressive function through PTEN.

Marina Corral Spence/Nature Publishing Group

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Authors and Affiliations

  1. John P. Ray is in the Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.,

    John P Ray

  2. Joe Craft is in the Department of Immunobiology and Department of Internal Medicine (Rheumatology), Yale University School of Medicine, New Haven, Connecticut, USA.,

    Joe Craft

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  1. John P Ray
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  2. Joe Craft
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Correspondence to Joe Craft.

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The authors declare no competing financial interests.

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Ray, J., Craft, J. PTENtiating autoimmunity through Treg cell deregulation. Nat Immunol 16, 139–140 (2015). https://doi.org/10.1038/ni.3082

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