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RNA exosomes keep endogenous RNA under the radar

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The unfolded protein response produces modified endogenous RNA substrates for host cytosolic sensors of RNA, which may lead to production of the interferons IFN-α and IFN-β. The accrual of modified RNA is prevented by an RNA nuclease.

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Figure 1: Cytosolic nucleases regulate host responses to exogenous and endogenous nucleic acids.

Debbie Maizels/Nature Publishing Group

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Authors and Affiliations

  1. Yaming Wang and Marco Colonna are with the Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.,

    Yaming Wang & Marco Colonna

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  1. Yaming Wang
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  2. Marco Colonna
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Correspondence to Marco Colonna.

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The authors declare no competing financial interests.

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Wang, Y., Colonna, M. RNA exosomes keep endogenous RNA under the radar. Nat Immunol 15, 830–831 (2014). https://doi.org/10.1038/ni.2966

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