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cASCading specks

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Inflammasome-driven inflammation extends into the extracellular space and to neighboring cells through the passive release of specks consisting of the adaptor ASC; this perpetuates the innate immune response and adds a dimension beyond interleukin 1 to autoinflammation.

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Figure 1: The release of ASC specks beyond macrophage borders can trigger an inflammatory cascade.

Debbie Maizels/Nature Publishing Group

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Authors and Affiliations

  1. Lori Broderick is in the Department of Pediatrics, University of California, La Jolla, San Diego, California, USA, and Rady Children's Hospital San Diego, San Diego, California, USA.,

    Lori Broderick

  2. Hal M. Hoffman is in the Department of Pediatrics, the Department of Medicine, University of California, La Jolla, San Diego, California, USA, University of California, La Jolla, San Diego, California, USA, and Rady Children's Hospital San Diego, San Diego, California, USA.,

    Hal M Hoffman

Authors
  1. Lori Broderick
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  2. Hal M Hoffman
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Correspondence to Hal M Hoffman.

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Competing interests

H.M.H. is a consultant for SOBI, Novartis and Regeneron.

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Broderick, L., Hoffman, H. cASCading specks. Nat Immunol 15, 698–700 (2014). https://doi.org/10.1038/ni.2942

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