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New ingredients for brewing CD4+T (cells): TCF-1 and LEF-1

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The transcription factors TCF-1 and LEF-1 have diverse roles in differentiation into the CD4+ lineage through means both dependent on and independent of the transcription factor Th-POK.

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Figure 1: Role of TCF-1 and LEF-1 in regulating the CD4+ lineage 'choice'.

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Authors and Affiliations

  1. Jayati Mookerjee-Basu & Dietmar J. Kappes are with the Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.,

    Jayati Mookerjee-Basu & Dietmar J Kappes

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  1. Jayati Mookerjee-Basu
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  2. Dietmar J Kappes
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Correspondence to Dietmar J Kappes.

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Mookerjee-Basu, J., Kappes, D. New ingredients for brewing CD4+T (cells): TCF-1 and LEF-1. Nat Immunol 15, 593–594 (2014). https://doi.org/10.1038/ni.2927

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