Although it is generally considered a proinflammatory cytokine, interleukin 6 (IL-6) has anti-inflammatory effects in macrophages by sensitizing them to IL-4 through upregulation of the IL-4 receptor.
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Katie Vicari
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Reilly, S., Saltiel, A. Countering inflammatory signals in obesity. Nat Immunol 15, 410–411 (2014). https://doi.org/10.1038/ni.2874
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DOI: https://doi.org/10.1038/ni.2874
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