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New inhibitory signaling by CTLA-4

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CTLA-4 is a potent inhibitor of T cell population expansion. The PIX-GIT2-PAK2 complex is recruited to the cytoplasmic domain of CTLA-4 via the kinase PKC-η, which suggests a previously unrecognized aspect of signal transduction via CTLA-4 in immunoregulation.

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Figure 1: Subcellular constraints of CTLA-4 signaling.

Katie Vicari

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Authors and Affiliations

  1. Christoph Wülfing, Helen M. Tunbridge and David C. Wraith are with the School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.,

    Christoph Wülfing, Helen M Tunbridge & David C Wraith

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  1. Christoph Wülfing
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  2. Helen M Tunbridge
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  3. David C Wraith
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Correspondence to Christoph Wülfing.

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The authors declare no competing financial interests.

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Wülfing, C., Tunbridge, H. & Wraith, D. New inhibitory signaling by CTLA-4. Nat Immunol 15, 408–409 (2014). https://doi.org/10.1038/ni.2870

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