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VE-cadherin phosphorylation decides: vascular permeability or diapedesis

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Phosphorylation of the adhesion molecule VE-cadherin at tyrosine residues modulates the opening of endothelial junctions during inflammatory reactions. The replacement of two distinct residues in VE-cadherin shows that Tyr685 regulates vascular permeability and Tyr731 regulates leukocyte diapedesis in vivo.

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Figure 1: Mechanisms for the in vivo control of leukocyte diapedesis and vascular permeability by phosphorylated VE-cadherin.

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Authors and Affiliations

  1. Adama Sidibé and Beat A. Imhof are in the Department of Pathology and Immunology, Centre Medical Universitaire, University of Geneva, Geneva, Switzerland.,

    Adama Sidibé & Beat A Imhof

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  1. Adama Sidibé
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  2. Beat A Imhof
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Correspondence to Beat A Imhof.

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The authors declare no competing financial interests.

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Sidibé, A., Imhof, B. VE-cadherin phosphorylation decides: vascular permeability or diapedesis. Nat Immunol 15, 215–217 (2014). https://doi.org/10.1038/ni.2825

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