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Old HDL learns a new (anti-inflammatory) trick

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In addition to its canonical role in reverse cholesterol transport, high-density lipoprotein can suppress inflammation in target cells through the induction of Atf3, which encodes a well-known transcriptional repressor.

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Figure 1: HDL suppresses TLR ligand–induced inflammation via activation of Atf3.

Marina Corral Spence

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Authors and Affiliations

  1. Justin I. Odegaard is with the Cardiovascular Research Institute, University of California, San Francisco, California, USA.,

    Justin I Odegaard

  2. the Department of Physiology and the Department of Medicine, Ajay Chawla is with the Cardiovascular Research Institute, University of California, San Francisco, California, USA.,

    Ajay Chawla

Authors
  1. Justin I Odegaard
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  2. Ajay Chawla
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Correspondence to Ajay Chawla.

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The authors declare no competing financial interests.

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Odegaard, J., Chawla, A. Old HDL learns a new (anti-inflammatory) trick. Nat Immunol 15, 138–139 (2014). https://doi.org/10.1038/ni.2798

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