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ADAPted secretion of cytokines in NK cells

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A signaling module consisting of the adaptor ADAP and the Carma1–Bcl-10–MALT1 (CBM)–TAK1 signalosome has been shown to selectively induce cytokine secretion but not cytotoxicity in natural killer cells.

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Figure 1: Possible model for the production of IFN-γ by and induction of cytotoxicity in NK cells.

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Authors and Affiliations

  1. Eric Vivier is with the Centre d'Immunologie de Marseille-Luminy, INSERM U1104, Marseille, France, CNRS UMR7280, Marseille, France, Aix Marseille Université UM2, Marseille, France, and Service d'Immunologie, Assistance Publique–Hôpitaux de Marseille, Hôpital de la Conception, Marseille, France.,

    Eric Vivier

  2. Sophie Ugolini is with the Centre d'Immunologie de Marseille-Luminy, INSERM U1104, Marseille, France, CNRS UMR7280, Marseille, France, and Aix Marseille Université UM2, Marseille, France.,

    Sophie Ugolini

  3. Jacques A. Nunès is with the Centre de Recherche en Cancérologie de Marseille, INSERM U1068, Marseille, France, CNRS, UMR7258, Marseille, France, Aix-Marseille Université UM105, Marseille, France, and Institut Paoli-Calmettes, Marseille, France.,

    Jacques A Nunès

Authors
  1. Eric Vivier
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  2. Sophie Ugolini
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  3. Jacques A Nunès
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Corresponding author

Correspondence to Eric Vivier.

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Competing interests

E.V. is cofounder and shareholder of Innate Pharma.

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Vivier, E., Ugolini, S. & Nunès, J. ADAPted secretion of cytokines in NK cells. Nat Immunol 14, 1108–1110 (2013). https://doi.org/10.1038/ni.2737

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