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GATA-3 controls self-renewal in stressed HSCs

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The transcription factor GATA-3 is expressed in quiescent hematopoietic stem cells (HSCs) with long-term repopulating ability. Stress-mediated activation of HSCs promotes localization of GATA-3 to the nucleus in a manner dependent on the mitogen-activated protein kinase p38α and restricts self-renewal.

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Figure 1: The role of GATA-3 under steady-state conditions and stress-induced activation of HSCs.

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Authors and Affiliations

  1. Toshimi Yoshida and Katia Georgopoulos are in the Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.,

    Toshimi Yoshida & Katia Georgopoulos

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  1. Toshimi Yoshida
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  2. Katia Georgopoulos
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Correspondence to Katia Georgopoulos.

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The authors declare no competing financial interests.

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Yoshida, T., Georgopoulos, K. GATA-3 controls self-renewal in stressed HSCs. Nat Immunol 14, 1032–1033 (2013). https://doi.org/10.1038/ni.2715

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