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IL-1 signaling in atherosclerosis: sibling rivalry

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Signaling via the interleukin 1 (IL-1) family, particularly by IL-1β, has long been linked to the pathogenesis of atherosclerosis. Findings that atherogenic fatty acids induce IL-1α to promote vascular inflammation identify a key role for this less-well-studied cytokine.

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Figure 1: Regulation of members of the IL-1 family in macrophages during atherosclerosis.

Katie Vicari

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Authors and Affiliations

  1. Frederick J. Sheedy is with the Institute of Molecular Medicine, Trinity College, St. James' Hospital, Dublin, Ireland.,

    Frederick J Sheedy

  2. Leon H. Charney Division of Cardiology, Department of Medicine, Kathryn J. Moore is with the Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine, New York, New York, USA.,

    Kathryn J Moore

Authors
  1. Frederick J Sheedy
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  2. Kathryn J Moore
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Correspondence to Kathryn J Moore.

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The authors declare no competing financial interests.

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Sheedy, F., Moore, K. IL-1 signaling in atherosclerosis: sibling rivalry. Nat Immunol 14, 1030–1032 (2013). https://doi.org/10.1038/ni.2711

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