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When metabolism met immunology

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Obesity induces metabolic stress and is associated with inflammation. A cellular pathway now links SIRT2, a deacetylase involved in metabolic processes, to cytoskeleton remodelling and activation of the NLRP3 inflammasome.

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Figure 1: Modulation of inflammation by cellular nutrients in macrophages.

Katie vicari

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Authors and Affiliations

  1. Marc Y. Donath is in the Department of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland.,

    Marc Y Donath

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  1. Marc Y Donath
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Correspondence to Marc Y Donath.

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Donath, M. When metabolism met immunology. Nat Immunol 14, 421–422 (2013). https://doi.org/10.1038/ni.2591

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