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High-affinity IgA needs TH17 cell functional plasticity

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The conversion of cells of the TH17 subset of helper T cells that previously expressed interleukin 17A (IL-17A) and the transcription factor RORγt into follicular helper T cells is needed to generate antigen-specific immunoglobulin A in gut mucosa, which suggests new connections in the cognate control of regional adaptive immunity.

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Figure 1: TH17 cells convert into IgA-inducing TFH cells in the intestinal mucosa.

Katie vicari

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Authors and Affiliations

  1. Pierre J. Milpied and Michael G. McHeyzer-Williams are in the Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla California, USA.,

    Pierre J Milpied & Michael G McHeyzer-Williams

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  1. Pierre J Milpied
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  2. Michael G McHeyzer-Williams
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Correspondence to Michael G McHeyzer-Williams.

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The authors declare no competing financial interests.

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Milpied, P., McHeyzer-Williams, M. High-affinity IgA needs TH17 cell functional plasticity. Nat Immunol 14, 313–315 (2013). https://doi.org/10.1038/ni.2567

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