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Balancing pro- and anti-inflammatory TLR4 signaling

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Limiting immune responses is critical for protecting the host from harm. The p110δ isoform of the kinase PI(3)K acts as a balance between pro- and anti-inflammatory TLR4 signaling in dendritic cells.

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Figure 1: Model for regulation of the subcellular shuttling of TLR4 by p110δ and the resulting cytokine shift.

Debbie Maizels

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Authors and Affiliations

  1. Sabine Siegemund and Karsten Sauer are in the Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.,

    Sabine Siegemund & Karsten Sauer

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  1. Sabine Siegemund
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  2. Karsten Sauer
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Correspondence to Karsten Sauer.

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The authors declare no competing financial interests.

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Siegemund, S., Sauer, K. Balancing pro- and anti-inflammatory TLR4 signaling. Nat Immunol 13, 1031–1033 (2012). https://doi.org/10.1038/ni.2452

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