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TBK1 suppression of IgA in the NIK of time

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The kinase TBK1 participates in signaling pathways that induce antimicrobial responses. TBK1 is also necessary for the suppression of excessive production of immunoglobulin A by accelerating destruction of the kinase NIK.

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Figure 1: Constitutive and regulated destruction of NIK modulates IgA production in B cells.

Debbie Maizels

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Authors and Affiliations

  1. Richard J. Bram is in the Department of Pediatric and Adolescent Medicine, Mayo Clinic Foundation, Rochester, Minnesota, USA.,

    Richard J Bram

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  1. Richard J Bram
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Correspondence to Richard J Bram.

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Competing interests

R.J.B. is listed as a coinventor on patents related to the gene encoding TACI.

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Bram, R. TBK1 suppression of IgA in the NIK of time. Nat Immunol 13, 1027–1029 (2012). https://doi.org/10.1038/ni.2451

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