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The ubiquitous nature of IL-17

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The deubiquitinating enzyme USP25 restricts ubiquitination of the adaptors TRAF5 and TRAF6 and signaling via interleukin 17 and thus joins several ubiquitin-modifying enzymes already known to regulate this biomedically important pathway.

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Figure 1: USP25 restricts the ubiquitination of TRAF5 and TRAF6 during signaling via IL-17R.

Debbie Maizels

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Authors and Affiliations

  1. Averil I. Ma is in the Department of Medicine, University of California at San Francisco, San Francisco, California, USA.,

    Averil I Ma

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  1. Averil I Ma
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Correspondence to Averil I Ma.

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Ma, A. The ubiquitous nature of IL-17. Nat Immunol 13, 1034–1035 (2012). https://doi.org/10.1038/ni.2448

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