A previously unknown protein, Tespa1, that regulates the thymocyte positive-selection checkpoint has now been identified. The phenotype of Tespa1-deficient mice and the role of Tespa1 in thymocyte signaling are very similar to those of Themis-deficient mice and Themis itself, another recently described but unrelated protein.
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Gascoigne, N., Fu, G. Tespa1: another gatekeeper for positive selection. Nat Immunol 13, 530–532 (2012). https://doi.org/10.1038/ni.2315
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DOI: https://doi.org/10.1038/ni.2315
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