Interleukin-17 (IL-17) induces the recruitment of neutrophils to sites of inflammation. In a model of periodontitis, Del-1 is now described to be an inhibitor of IL-17 expression that suppresses the recruitment of neutrophils and the associated inflammation-mediated pathology.
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Khader, S. Restraining IL-17: Del-1 deals the blow. Nat Immunol 13, 433–435 (2012). https://doi.org/10.1038/ni.2290
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DOI: https://doi.org/10.1038/ni.2290
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