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A new path to IL-1β production controlled by caspase-8

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Maturation of the proinflammatory cytokine IL-1b is achieved mainly by the canonical caspase-1 inflammasome. An alternative caspase-8-dependent inflammasome that is engaged after stimulation with dectin-1 during fungal and mycobacterial infection has now been described.

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Figure 1: Activation of the noncanonical inflammasome in dendritic cells.

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Authors and Affiliations

  1. Jeremy Dupaul-Chicoine is in the Department of Biochemistry, McGill University, Montreal, Canada.,

    Jeremy Dupaul-Chicoine

  2. Maya Saleh is in the Department of Biochemistry, Department of Medicine and Department of Microbiology and Immunology, McGill University, Montreal, Canada.,

    Maya Saleh

Authors
  1. Jeremy Dupaul-Chicoine
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  2. Maya Saleh
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Correspondence to Maya Saleh.

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The authors declare no competing financial interests.

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Dupaul-Chicoine, J., Saleh, M. A new path to IL-1β production controlled by caspase-8. Nat Immunol 13, 211–212 (2012). https://doi.org/10.1038/ni.2241

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