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A rescue gone wrong

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Becoming covered in platelets rescues complement-opsonized blood-borne bacteria from rapid clearance by macrophages and redirects them to dendritic cells. Although this allows priming of T cells and the generation of immune memory, bacteria can exploit this route as a beachhead and disseminate throughout host tissues.

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Figure 1: As part of the innate immune response, macrophages can engulf and destroy opsonized bacteria.

Marina Corral

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Authors and Affiliations

  1. Steffen Jung is in the Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.,

    Steffen Jung

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  1. Steffen Jung
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Correspondence to Steffen Jung.

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The author declares no competing financial interests.

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Jung, S. A rescue gone wrong. Nat Immunol 12, 1137–1138 (2011). https://doi.org/10.1038/ni.2161

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