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Damage control: how HIV survives the editor APOBEC3G

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The antiviral factor APOBEC3G upregulates the expression of ligands for the activating receptor NKG2D via DNA damage induced by the viral protein Vpr in cells infected with human immunodeficiency virus. The virus overcomes greater susceptibility to natural killer cell–mediated lysis by targeting APOBEC3G for degradation.

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Figure 1: Model for the effect of APOBEC3G on NKG2D-L expression.

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Authors and Affiliations

  1. Department of Microbiology, J. Ludovic Croxford and Stephan Gasser are with the Immunology Programme, National University of Singapore, Singapore.,

    J Ludovic Croxford & Stephan Gasser

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  1. J Ludovic Croxford
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  2. Stephan Gasser
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Correspondence to Stephan Gasser.

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The authors declare no competing financial interests.

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Croxford, J., Gasser, S. Damage control: how HIV survives the editor APOBEC3G. Nat Immunol 12, 925–927 (2011). https://doi.org/10.1038/ni.2115

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