T cell tolerance is essential to the prevention of autoimmunity. The ubiquitin E3 ligase Peli1 acts as a negative regulator of T cell activation and contributes to the maintenance of self-tolerance.
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Moynagh, P. Peli1 (rel)ieves autoimmunity. Nat Immunol 12, 927–929 (2011). https://doi.org/10.1038/ni.2108
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DOI: https://doi.org/10.1038/ni.2108
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