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Micro RNAs are complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulation

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Abstract

Micro RNAs are a large family of noncoding RNAs of 21–22 nucleotides whose functions are generally unknown. Here a large subset of Drosophila micro RNAs is shown to be perfectly complementary to several classes of sequence motif previously demonstrated to mediate negative post-transcriptional regulation. These findings suggest a more general role for micro RNAs in gene regulation through the formation of RNA duplexes.

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Figure 1: The 5′ ends of many miRNAs are perfectly complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulation in Drosophila.

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Acknowledgements

E.C.L. is supported by Gerald Rubin and by the Cancer Research Fund of the Damon Runyon-Walter Winchell Foundation.

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  1. Department of Molecular and Cell Biology, University of California at Berkeley, 545 Life Sciences Addition #3200, Berkeley, 94720-3200, California

    Eric C. Lai

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  1. Eric C. Lai
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Correspondence to Eric C. Lai.

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Lai, E. Micro RNAs are complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulation. Nat Genet 30, 363–364 (2002). https://doi.org/10.1038/ng865

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