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FTO gains function

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Previous genome-wide association studies have identified a strong association between FTO and human obesity, although the mechanism by which FTO affects obesity remains unknown. A new study suggests that the obesity risk alleles are gain-of-function.

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Figure 1: Genomic organization of the FTO locus on chromosome 16 (16q12.2, at 52.3–52.4 Mbp).

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Authors and Affiliations

  1. George Stratigopoulos and Rudolph L. Leibel are at the Division of Molecular Genetics and the Naomi Berrie Diabetes Center at Columbia University, New York, New York, USA.,

    George Stratigopoulos & Rudolph L Leibel

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  1. George Stratigopoulos
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  2. Rudolph L Leibel
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Correspondence to Rudolph L Leibel.

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The authors declare no competing financial interests.

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Stratigopoulos, G., Leibel, R. FTO gains function. Nat Genet 42, 1038–1039 (2010). https://doi.org/10.1038/ng1210-1038

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