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Evidence for a common pathway linking neurodegenerative diseases

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In the largest Parkinson's disease genome-wide association studies to date, common variants in three familiar genes—SNCA, MAPT and LRRK2—and two new loci are found to increase disease susceptibility. The studies suggest genetic heterogeneity for Parkinson's disease risk in different human populations and lend support to the idea of a common pathway for Parkinson's and Alzheimer's diseases.

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Figure 1: Proposed link between Parkinson's disease and Alzheimer's disease.

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Authors and Affiliations

  1. Department of Neurology, Joshua M. Shulman and Philip L. De Jager are at the Program in Translational Neuropsychiatric Genomics, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA and at the Program in Medical & Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.,

    Joshua M Shulman & Philip L De Jager

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  1. Joshua M Shulman
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  2. Philip L De Jager
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Correspondence to Philip L De Jager.

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Shulman, J., De Jager, P. Evidence for a common pathway linking neurodegenerative diseases. Nat Genet 41, 1261–1262 (2009). https://doi.org/10.1038/ng1209-1261

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