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New insights into the biological basis of genomic disorders

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Many clinical syndromes result from deletion or duplication of regions within the human genome. Two new studies demonstrate strong connections between such events and allelic recombination in humans, which in the future may enable researchers to better predict the locations of unstable genomic regions.

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Figure 1: Alternate resolution of meiotic recombination events involving allelic and nonallelic pairing of low-copy repeats (LCRs).

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Authors and Affiliations

  1. the Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, 02139, Massachusetts, USA

    Simon R Myers & Steven A McCarroll

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  1. Simon R Myers
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  2. Steven A McCarroll
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Myers, S., McCarroll, S. New insights into the biological basis of genomic disorders. Nat Genet 38, 1363–1364 (2006). https://doi.org/10.1038/ng1206-1363

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