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Making the commitment to meiosis

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Analysis of the phenotype of mouse germ cells deficient for the retinoic acid–responsive gene Stra8 provides insight into the timing of the commitment to enter meiosis in mammals. The observations suggest that, as in other eukaryotes, this commitment precedes (or coincides with) the commitment to premeiotic DNA replication.

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Figure 1: This flowchart depicts the steps of mammalian gametogenesis with an emphasis on the progression through mitosis and meiosis.

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Authors and Affiliations

  1. Departments of Genetics and Development and Obstetrics and Gynecology, The Institute of Human Nutrition, and The Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, 10032, New York, USA

    Debra J Wolgemuth

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  1. Debra J Wolgemuth
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Wolgemuth, D. Making the commitment to meiosis. Nat Genet 38, 1362–1363 (2006). https://doi.org/10.1038/ng1206-1362

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