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Toward a human epigenome

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Sequencing of genomes, including that of humans, has revolutionized our understanding of genome organization and accelerated the hunt for disease-causing mutations. New studies by the Human Epigenome Project (HEP) now highlight the importance and complexity of cytosine DNA methylation in tissue-specific regulation of gene expression.

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Figure 1: Tissue-specific DNA methylation and epigenetic heterogeneity among individuals.

Kim Caesar

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Authors and Affiliations

  1. Division of Human Cancer Genetics, Department of Molecular Genetics and Department of Molecular Virology, Immunology and Medical Genetics,

    Romulo M Brena, Tim H-M Huang & Christoph Plass

  2. Division of Human Cancer Genetics, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, 43210, Ohio, USA

    Romulo M Brena, Tim H-M Huang & Christoph Plass

Authors
  1. Romulo M Brena
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  2. Tim H-M Huang
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  3. Christoph Plass
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Brena, R., Huang, TM. & Plass, C. Toward a human epigenome. Nat Genet 38, 1359–1360 (2006). https://doi.org/10.1038/ng1206-1359

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