Skip to main content
SpringerLink
Log in

Power tools for human genetics

  • News & Views
  • Published:

From Nature Genetics

View current issue Submit your manuscript

Genome-wide association studies have the potential to identify systematically the contributions of common genetic variants to human disease, but the tools to carry out such studies have been incomplete. Assessments of the HapMap resource suggest that the tools are now in hand, but care is required in their use for study design, analysis and interpretation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Schematic of a genomic region to be tested for association with a phenotype.

References

  1. Kruglyak, L. & Nickerson, D.A. Nat. Genet. 27, 234–236 (2001).

    Article  CAS  PubMed  Google Scholar 

  2. The International HapMap Consortium. Nature 437, 1299–1320 (2005).

  3. Kruglyak, L. Nat. Genet. 22, 139–144 (1999).

    Article  CAS  PubMed  Google Scholar 

  4. Kruglyak, L. Proc. Natl. Acad. Sci. USA 96, 1170–1172 (1999).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Carlson, C.S. et al. Nat. Genet. 33, 518–521 (2003).

    Article  CAS  PubMed  Google Scholar 

  6. de Bakker, P.I. et al. Nat. Genet. 37, 1217–1223 (2005).

    Article  CAS  PubMed  Google Scholar 

  7. Zeggini, E. et al. Nat. Genet., advance online publication 30 October 2005 (10.1038/ng1670).

  8. Klein, R.J. et al. Science 308, 385–389 (2005).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Carlson, C.S. et al. Am. J. Hum. Genet. 74, 106–120 (2004).

    Article  CAS  PubMed  Google Scholar 

  10. Rioux, J.D. et al. Nat. Genet. 29, 223–228 (2001).

    Article  CAS  PubMed  Google Scholar 

  11. Hinds, D.A. et al. Science 307, 1072–1079 (2005).

    Article  CAS  PubMed  Google Scholar 

  12. Margulies, M. et al. Nature 437, 376–380 (2005).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Shendure, J. et al. Science 309, 1728–1732 (2005).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. the Lewis-Sigler Institute for Integrative Genomics and Department of Ecology and Evolutionary Biology, Carl Icahn Laboratory, Princeton University, Princeton, 08544, New Jersey, USA

    Leonid Kruglyak

Authors
  1. Leonid Kruglyak
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kruglyak, L. Power tools for human genetics. Nat Genet 37, 1299–1300 (2005). https://doi.org/10.1038/ng1205-1299

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng1205-1299

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation