Skip to main content
SpringerLink
Log in

Quantitative trait loci analysis affecting contextual conditioning in mice

  • Letter
  • Published:

From Nature Genetics

View current issue Submit your manuscript

Abstract

In an extensive backcross of mice between C3H/HeJ (C3H) and C57BL/6J (B6), we sought to map genes that influence learning and memory as measured by performance in a contextual fear-conditioning paradigm. Our results indicate that there are several genetic regions that have a strong influence on performance in this paradigm. The strongest influences map to the proximal and distal ends of chromosome 1 (lod scores of 5.14 and 4.76, respectively). Other chromosomal regions (chromosomes 3, 7, 8, 9 and 18) were also identified as candidates for regions containing genes influencing contextual fear conditioning, with lod scores ranging from 1.8 to 2.7.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bourtchuladze, R. et al. Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell. 79, 59–68 (1994).

    Article  CAS  Google Scholar 

  2. Silva, A.J. et al. Alpha calcium/calmodulin kinase II mutant mice: deficient long-term potentiation and impaired spatial learning. Cold Spring Harbor Symp. Quant. Biol. 57, 527–539 (1992).

    Article  CAS  Google Scholar 

  3. Silva, A.J. et al. Impaired learning in mice with abnormal short-lived plasticity. Curr. Biol. 6, 1509–1518 (1996).

    Article  CAS  Google Scholar 

  4. Aiba, A. et al. Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice. Cell. 79, 365–375 (1994).

    Article  CAS  Google Scholar 

  5. Kim, J.J. & Fanselow, M.S. Modality-specific retrograde amnesia of fear. Science. 256, 675–677 (1992).

    Article  CAS  Google Scholar 

  6. Phillips, R.G. & LeDoux, J.E. Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav. Neurosci. 106, 274–285 (1992).

    Article  CAS  Google Scholar 

  7. Lander, E. & Kruglyak, L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genet. 11, 241–247 (1995).

    Article  CAS  Google Scholar 

  8. Lander, E.S. & Botstein, D. Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics. 121, 185–199 (1989).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Flint, J. et al. A simple genetic basis for a complex psychological trait in laboratorymice. Science. 269, 1432–1435 (1995).

    Article  CAS  Google Scholar 

  10. Tarricone, B.J., Hingtgen, J.N., Belknap, J.K., Mitchell, S.R. & Nurnberger, J.I.,Jr., Quantitative trait loci associated with the behavioral response of BXD recombinant inbred mice to restraint stress: a preliminary communication. Behav. Genet. 25, 489–495 (1995).

    Article  CAS  Google Scholar 

  11. Wehner, J.M. et al. Quantitative trait loci analysis of contextual fear conditioning in mice. Nature Genet. 17, 331–334 (1997).

    Article  CAS  Google Scholar 

  12. Paylor, R., Tracy, R., Wehner, J. & Rudy, J.W. DBA/2 and C57BL/6 mice differ in contextual fear but not auditory fear conditioning. Behav.Neurosci. 108, 810–817 (1994).

    Article  CAS  Google Scholar 

  13. Paterson, A.M. et al. Resolution of quantitative traits into Mendelian factors using a complete linkage map of restriction fragment length polymorphisms.. Nature. 335, 721–726 (1988).

    Article  CAS  Google Scholar 

  14. Laird, P.W. et al. Simplified mammalian DNA isolation procedure. Nucleic Acids Res. 19, 4293 (1991).

    Article  CAS  Google Scholar 

  15. Dietrich, W. et al. A genetic map of the mouse suitable for typing intraspecific crosses. Genetics. 131, 423–447 (1992).

    CAS  PubMed  PubMed Central  Google Scholar 

  16. Dietrich, W. et al. A genetic map of the mouse with 4,006 simple sequence length polymorphisms. Nature Genet. 7, 220–245 (1994).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Psychology and Biomedical Sciences, University at Albany, State University of New York, Albany, New York, 12222, USA

    Barbara Caldarone, Carlos Saavedra, Kathleen Tartaglia, Bruce C Dudek & Lorraine Flaherty

  2. Molecular Genetics Program, Wadsworth Center, Albany, New York, 12201-2002, USA

    Barbara Caldarone, Carlos Saavedra, Kathleen Tartaglia & Lorraine Flaherty

  3. The Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado, USA

    Jeanne M Wehner & Lorraine Flaherty

Authors
  1. Barbara Caldarone
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Carlos Saavedra
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kathleen Tartaglia
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jeanne M Wehner
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Bruce C Dudek
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Lorraine Flaherty
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Caldarone, B., Saavedra, C., Tartaglia, K. et al. Quantitative trait loci analysis affecting contextual conditioning in mice. Nat Genet 17, 335–337 (1997). https://doi.org/10.1038/ng1197-335

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng1197-335

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation