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Dax1 is required for testis determination

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Abstract

The orphan nuclear receptor, Dax1, was originally proposed to act as an 'anti-testis' factor. We find, however, that Nr0b1 (also called Dax1 and Ahch, which encodes Dax1) is in fact required for testis differentiation.

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Figure 1: XYpos Nr0b1−/Y mice were indistinguishable from XX mice.
Figure 2: XYpos Nr0b1−/Y gonads developed as ovaries.

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Acknowledgements

This work was supported by grants from the US National Institutes of Health.

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Authors and Affiliations

  1. Division of Endocrinology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, 60611, Illinois, USA

    Joshua J. Meeks, Jeffrey Weiss & J. Larry Jameson

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  1. Joshua J. Meeks
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  2. Jeffrey Weiss
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  3. J. Larry Jameson
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Correspondence to J. Larry Jameson.

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The authors declare no competing financial interests.

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Meeks, J., Weiss, J. & Jameson, J. Dax1 is required for testis determination. Nat Genet 34, 32–33 (2003). https://doi.org/10.1038/ng1141

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