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Building in resistance to endothelial cell death

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A new study in zebrafish shows that Birc2, a member of the inhibitor of apoptosis (IAP) family, is required for endothelial cell survival. This discovery highlights an important in vivo function of this molecule and suggests potential avenues for the development of new antiangiogenic therapies.

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Figure 1: Birc2 regulates endothelial cell survival.

Kim Caesar

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Authors and Affiliations

  1. Massimiliano Mazzone, Carmen Ruiz de Almodovar and Peter Carmeliet are at the Center for Transgene Technology and Gene Therapy, Flanders Institute for Biotechnology (VIB), Katholieke Universiteit Leuven (K.U. Leuven), 3000, Leuven, Belgium. peter.carmeliet@med.kuleuven.be,

    Massimiliano Mazzone, Carmen Ruiz de Almodovar & Peter Carmeliet

Authors
  1. Massimiliano Mazzone
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  2. Carmen Ruiz de Almodovar
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  3. Peter Carmeliet
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Mazzone, M., de Almodovar, C. & Carmeliet, P. Building in resistance to endothelial cell death. Nat Genet 39, 1308–1309 (2007). https://doi.org/10.1038/ng1107-1308

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