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Transcription in the loop

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A new study shows that during transcription, the TH2 interleukin gene cluster is organized into several small chromatin loops connected at their base by the protein SATB1. This first detailed glimpse of chromatin folding provides a new perspective on the coordination of cell type–specific gene expression.

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Figure 1: Chromatin loops and coordination of gene transcription.

Kim Caesar

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Authors and Affiliations

  1. Department of Development and Genetics, Evolution Biology Centre, Norbyvägan 18A, Uppsala University, Uppsala, SE-752 36, Sweden

    Anita Göndör & Rolf Ohlsson

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  1. Anita Göndör
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  2. Rolf Ohlsson
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Göndör, A., Ohlsson, R. Transcription in the loop. Nat Genet 38, 1229–1230 (2006). https://doi.org/10.1038/ng1106-1229

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