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Lethal combinations

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Synthetic lethality occurs when two otherwise nonlethal mutations together result in an inviable cell. A new study describes a rapid approach to identify synthetic lethal mutations in yeast.

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Figure 1: Comparison of genome-wide synthetic lethal screening methods.

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Authors and Affiliations

  1. the Departments of Genome Sciences and Medicine,

    Chandra L Tucker & Stanley Fields

  2. Departments of Genome Sciences and Medicine and Howard Hughes Medical Institute at University of Washington, Box 357730, Seattle, 98195, Washington, USA

    Chandra L Tucker & Stanley Fields

Authors
  1. Chandra L Tucker
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  2. Stanley Fields
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Tucker, C., Fields, S. Lethal combinations. Nat Genet 35, 204–205 (2003). https://doi.org/10.1038/ng1103-204

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