Skip to main content

Advertisement

Log in

Alzheimer’s disease beyond APOE

  • News & Views
  • Published:

From Nature Genetics

View current issue Submit your manuscript

Two genome-wide association studies together report three new susceptibility loci for late-onset Alzheimer’s disease. CLU, PICALM and CR1 may be involved in amyloid-β clearance from the brain.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: The balance between APP processing and clearance in a model of AD pathogenesis.

References

  1. Ferri, C.P. et al. Lancet 366, 2112–2117 (2005).

    Article  Google Scholar 

  2. Blennow, K., de Leon, M.J. & Zetterberg, H. Lancet 368, 387–403 (2006).

    Article  CAS  Google Scholar 

  3. Lambert, J.-C. et al. Nat. Genet. 41, 1094–1099 (2009).

    Article  CAS  Google Scholar 

  4. Harold, D. et al. Nat. Genet. 41, 1088–1093 (2009).

    Article  CAS  Google Scholar 

  5. Goate, A. et al. Nature 349, 704–706 (1991).

    Article  CAS  Google Scholar 

  6. Sherrington, R. et al. Nature 375, 754–760 (1995).

    Article  CAS  Google Scholar 

  7. Levy-Lahad, E. et al. Science 269, 973–977 (1995).

    Article  CAS  Google Scholar 

  8. Corder, E.H. et al. Science 261, 921–923 (1993).

    Article  CAS  Google Scholar 

  9. Corder, E.H. et al. Nat. Genet. 7, 180–184 (1994).

    CAS  Google Scholar 

  10. Waring, S.C. & Rosenberg, R. Arch. Neurol. 65, 329–334 (2008).

    Google Scholar 

  11. Ashford, J.W. & Mortimer, J.A. J. Alzheimers Dis. 4, 169–177 (2002).

    Google Scholar 

  12. Carrasquillo, M.M. et al. Nat. Genet. 41, 192–198 (2009).

    Article  CAS  Google Scholar 

  13. Laurén, J. et al. Nature 457, 1128–1132 (2009).

    Article  Google Scholar 

  14. Nikolaev, A. et al. Nature 457, 981–989 (2009).

    Article  CAS  Google Scholar 

  15. Wyss-Coray, T. et al. Proc. Natl. Acad. Sci. USA 99, 10837–10842 (2002).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Michael A van Es or Leonard H van den Berg.

Rights and permissions

Reprints and permissions

About this article

Cite this article

van Es, M., van den Berg, L. Alzheimer’s disease beyond APOE. Nat Genet 41, 1047–1048 (2009). https://doi.org/10.1038/ng1009-1047

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng1009-1047

  • Springer Nature America, Inc.

This article is cited by

Navigation