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Rhythm is not enough

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MAGEL2 is located in a cluster of imprinted genes on human chromosome 15 that is implicated in Prader-Willi syndrome (PWS). A new study shows that mice deficient for this gene show altered behavioral rhythmicity that resembles some features of PWS.

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Figure 1: An autonomous, self-sustained oscillator acts as the core of the biological clock.

Kim Caesar

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Horsthemke, B. Rhythm is not enough. Nat Genet 39, 1190–1191 (2007). https://doi.org/10.1038/ng1007-1190

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