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A WNK in the kidney controls blood pressure

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Precise control of sodium excretion by the kidney is critical for maintaining fluid and electrolyte homeostasis. A new mouse model provides compelling evidence that a kinase, WNK4, provides key signals for regulating blood pressure and potassium balance by controlling the structure and function of the distal convoluted tubule.

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Figure 1: Schematic depicting the sodium-chloride cotransporter (NCC), the potassium channel (ROMK), the sodium channel (ENaC), WNK1 and WNK4 in a renal epithelial cell in the latter portion of the distal convoluted tubule.

Kim Caesar

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Authors and Affiliations

  1. Division of Nephrology, Department of Medicine, Duke University and the Durham Veterans Administration Medical Centers, Durham, 27710, North Carolina, USA

    Thomas M Coffman

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  1. Thomas M Coffman
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Coffman, T. A WNK in the kidney controls blood pressure. Nat Genet 38, 1105–1106 (2006). https://doi.org/10.1038/ng1006-1105

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