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(Re)modeling the transcriptional enhancer

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Transcriptional cis-regulatory modules have a fundamental role in regulating eukaryotic gene expression. A new study shows how computational modeling can test hypotheses about how regulatory elements function, with results that challenge conventional views of their organization.

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Figure 1: Different arrangements of cis-regulatory modules (CRMs).

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Authors and Affiliations

  1. Department of Biochemistry, and the Department of Molecular and Cellular Biology, State University of New York at Buffalo, Buffalo, New York 14214, USA, Roswell Park Cancer Institute, Buffalo, 14263, New York, USA

    Marc S Halfon

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  1. Marc S Halfon
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Halfon, M. (Re)modeling the transcriptional enhancer. Nat Genet 38, 1102–1103 (2006). https://doi.org/10.1038/ng1006-1102

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