Groups of interacting proteins define functional modules that govern a cell's activity. A new study suggests that specific interaction motifs and their constituents are highly conserved across species, identifying potential functional modules used in the evolutionary process.
This is a preview of subscription content, log in via an institution to check access.
References
Wuchty, S. et al. Nat. Genet. 35, 176–179 (2003).
Barabasi, A.-L. Linked (Perseus, Cambridge, Massachusetts, 2002).
Dorogovtsev, S.N. & Mendes, J.F.F. Evolution of Networks (Oxford University Press, Oxford, 2003).
Hodgman, T.C. Bioinformatics 16, 10–15 (2000).
Oltvai, Z.N. & Barabasi, A.-L. Science 298, 763–764 (2002).
Ravasz, E. et al. Science 297, 1551–1555 (2002).
Hartwell, L.H. et al. Nature 402, C47–C52 (1999).
Milo, R. et al. Science 298, 824–827 (2002).
Vazquez, A. et al. Complexus 1, 38–42 (2003).
Pastor-Satorras, R. et al. J. Theor. Biol. 222, 199–210 (2003).
Hishigaki, H. et al. Yeast 18, 523–531 (2001).
Vazquez, A. et al. Nat. Biotechnol. 21, 697–700 (2003).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Vespignani, A. Evolution thinks modular. Nat Genet 35, 118–119 (2003). https://doi.org/10.1038/ng1003-118
Issue Date:
DOI: https://doi.org/10.1038/ng1003-118
- Springer Nature America, Inc.
This article is cited by
-
Statistical properties of complex network for seismicity using depth-incorporated influence radius
Acta Geophysica (2019)
-
Stability of Control Networks in Autonomous Homeostatic Regulation of Stem Cell Lineages
Bulletin of Mathematical Biology (2018)
-
Interlog protein network: an evolutionary benchmark of protein interaction networks for the evaluation of clustering algorithms
BMC Bioinformatics (2015)
-
Integrative approaches for finding modular structure in biological networks
Nature Reviews Genetics (2013)
-
A methodology for detecting the orthology signal in a PPI network at a functional complex level
BMC Bioinformatics (2012)