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Variable evolutionary signatures at the heart of enhancers

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What is the best way to identify regulatory DNA sequences such as enhancers, promoters, insulators and silencers? A new study shows that specific binding by a coactivator protein identifies enhancers that are invisible to common detection methods based on evolutionary constraint.

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Figure 1: Binding by the transcriptional coactivator p300 identifies enhancers that are not conserved in all vertebrates.

References

  1. Dermitzakis, E.T., Reymond, A. & Antonarakis, S.E. Nat. Rev. Genet. 6, 151–157 (2005).

    Article  CAS  PubMed  Google Scholar 

  2. Pennacchio, L.A. et al. Nature 444, 499–502 (2006).

    Article  CAS  PubMed  Google Scholar 

  3. Blow, M.J. et al. Nat. Genet. 42, 806–810 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Heintzman, N.D. et al. Nat. Genet. 39, 311–318 (2007).

    Article  CAS  PubMed  Google Scholar 

  5. Birney, E. et al. Nature 447, 799–816 (2007).

    Article  CAS  PubMed  Google Scholar 

  6. King, D.C. et al. Genome Res. 17, 775–786 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Schmidt, D. et al. Science 328, 1036–1040 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Margulies, E.H. et al. Genome Res. 17, 760–774 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Ross C. Hardison is at the Pennsylvania State University Department of Biochemistry and Molecular Biology, University Park, Pennsylvania, USA.,

    Ross C Hardison

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  1. Ross C Hardison
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Correspondence to Ross C Hardison.

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Hardison, R. Variable evolutionary signatures at the heart of enhancers. Nat Genet 42, 734–735 (2010). https://doi.org/10.1038/ng0910-734

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