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An uphill battle toward pluripotency

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The discovery that a cocktail of transcription factors can reprogram somatic cells into induced pluripotent stem (iPS) cells keeps revealing new secrets of cell fate specification. A new study with hematopoietic cells shows that progenitor cells are far more susceptible than differentiated cells to reprogramming.

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Figure 1: Inverse correlation between iPS reprogramming frequencies and hematopoietic differentiation stage (data modified from ref. 3).

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Authors and Affiliations

  1. Thomas Graf is at the Center for Genomic Regulation, Institució Catalana de Recerca i Estudis Avançats and Pompeu Fabra University, Barcelona, Spain. thomas.graf@crg.es,

    Thomas Graf

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  1. Thomas Graf
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Graf, T. An uphill battle toward pluripotency. Nat Genet 41, 960–961 (2009). https://doi.org/10.1038/ng0909-960

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