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Casting a wider net for diabetes susceptibility genes

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Recent successes in identifying loci involved in predisposition to type 2 diabetes have been driven by genome-wide association studies in populations of European descent. A new discovery, using samples of East Asian origin, of diabetes susceptibility variants mapping to the KCNQ1 gene highlights the importance of extending these studies to a wider range of populations.

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Figure 1: Power to detect variants of similar effect size but differing risk-allele frequency.

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Authors and Affiliations

  1. Mark I. McCarthy is at the Oxford Centre for Diabetes, Endocrinology and Metabolism, the Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK, and the Oxford National Institute for Health Research Biomedical Research Centre, Oxford, UK. mark.mccarthy@drl.ox.ac.uk,

    Mark I McCarthy

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  1. Mark I McCarthy
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McCarthy, M. Casting a wider net for diabetes susceptibility genes. Nat Genet 40, 1039–1040 (2008). https://doi.org/10.1038/ng0908-1039

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