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IL-7Rα and multiple sclerosis risk

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The discovery of genetic risk factors for multiple sclerosis has proven difficult. IL-7Rα, encoded by IL7R, is a pleiomorphic cytokine receptor now implicated in the pathogenesis of multiple sclerosis in independently replicated genetic association studies.

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Figure 1: Large sample sizes are required to detect genetic associations of small effects, under any model of inheritance.

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Authors and Affiliations

  1. and the US Department of Veterans Affairs Medical Center, John B. Harley is in the Arthritis and Immunology Program at the Oklahoma Medical Research Foundation, 825 N.E. 13th Street, Oklahoma City, Oklahoma 73104, USA, Oklahoma City, Oklahoma 73104, USA. harley@omrf.org,

    John B Harley

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  1. John B Harley
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Harley, J. IL-7Rα and multiple sclerosis risk. Nat Genet 39, 1053–1054 (2007). https://doi.org/10.1038/ng0907-1053

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